ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

Page 1 of about 3 results

ey0020.7-6 | Gonadal Function and Fertility Issues in Childhood Cancer Survivors | ESPEYB20

7.6. The impact of vincristine on testicular development and function in childhood cancer

I Clark , MFH Brougham , N Spears , RT Mitchell

Brief summary: This is a systematic review on the effects of vincristine-containing regimens, commonly considered to have low gonadotoxicity, on human prepubertal testis, after the reports of testicular tissue abnormalities and severely impaired fertility due to vincristine exposure in prepubertal rodents.Twenty-four studies were identified that reported testicular development and fertility after treatment with vincristine-containing regimens. Only 9/24 ...
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ey0016.2-16 | Fetal and Neonatal Cortisol Physiology | ESPEYB16

2.16. Characterization of human adrenal steroidogenesis during fetal development

C Melau , JE Nielsen , H Frederiksen , K Kilcoyne , S Perlman , L Lundvall , LL Thuesen , K Juul Hare , AM Andersson , RT Mitchell , A Juul , A Jorgensen

J Clin Endocrinol Metab. 2018 Dec 21. [Epub ahead of print]. doi: 10.1210/jc.2018-01759.This study aimed to investigate Human fetal adrenal (HFA) steroidogenesis by analyzing adrenal glands from 1st and 2nd trimester. Steroidogenesis in the HFA is tightly regulated throughout the first and second trimesters, which is crucial because the adrenal steroid hormones affect the overall intrauterine endocri...
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ey0017.7-9 | Basic Science | ESPEYB17

7.9. The dynamic transcriptional cell atlas of testis development during human puberty

J Guo , X Nie , M Giebler , H Mlcochova , Y Wang , EJ Grow , Connect Donor , R Kim , M Tharmalingam , G Matilionyte , C Lindskog , DT Carrell , RT Mitchell , A Goriely , JM Hotaling , BR Cairns

To read the full abstract: Cell Stem Cell vol. 26,2 (2020): 262–276.e4. doi: https://www.sciencedirect.com/science/article/pii/S1934590919305235?via%3DihubThis paper describes a transcriptional analysis of human spermatogonial stem cells during puberty and the involvement of testosterone in Sertoli cell maturation.The...
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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